Increased levels of interleukin 8 (IL-8/CXCL8) and IL-1β were identified as prognostic indicators for the progression of PMF to MPN-BP, and TNF-alpha correlated with MPN-BP progression irrespective of the MPN subtype [5,42,43]. The gene discussed is CXCL8; the disease is myeloproliferative neoplasm.