Although the concept of surveilling or selectively destroying the CHIP clone before it can give rise to an overt disease was proposed several years ago [104], it has regained a lot of interest by the findings that CHIP/MPN-associated mutations were already acquired in early childhood or even in utero and thromboembolic events occur years before MPN diagnosis [34,73,105]. The gene discussed is STUB1; the disease is myeloproliferative disorder.