ADAR and neoplasm: The choice of Adar2 was dictated by the fact that although we observed that both enzymes are able to edit the RBM8A 3′UTR, ADAR1 levels are not significantly different between mesothelial and MPM cells (Hariharan et al., ms in preparation), and in the mouse model of mesothelioma development, we previously observed that Adar2 levels specifically increase during tumor development [15].