An important observation also shows that leukocytes obtained from patients with Addison’s disease, which is associated with reduced cortisol levels, have decreased intracellular levels of AnxA1, whilst patients with Cushing’s syndrome, which have with higher cortisol levels, have an increased expression of AnxA1, further corroborating the relationship between AnxA1 and GCs in disease [95]. Here, ANXA1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.