Ying et al. [98,99] demonstrated that Ang II can stimulate the activation and collagen deposition of lung fibroblasts through the NLRP3/caspase-1/IL-1β pathway, and autophagy can clear ROS, abrogate the ubiquitination of NLRP3 and inhibit the expression of IL-1β to reverse Ang II-mediated pulmonary fibrosis. The gene discussed is NLRP3; the disease is pulmonary fibrosis.