Ang II stimulates NADPH oxidase 4 (NOX4)-derived ROS and mitochondria-dependent ROS accumulation to aggravate hepatic fibrosis by activating HSCs through the IL-1β/NLRP3/Smad pathway and the TLR4/MyD88/NF-κB pathway [49]. This evidence concerns the gene NOX4 and Hepatic fibrosis.