During the past year, several studies have linked cholesterol metabolism with susceptibility to COVID-19 and the severity of the infection and serum LDL level is shown to be a predictor of poor disease prognosis We report downregulation of LDL particle receptor pathway activity in patients of ICU surviving from severe COVID-19 infection and genes PPARG, CD36, STAB1, ITGAV, and ANXA was downregulated in surviving patients with COVID-19. The gene discussed is PPARG; the disease is infection.