We have reported previously that, under the influence of cancer-conditioned media mimicking the cancer microenvironment, DPMSCs secrete a variety of anti-proliferative molecules, including IL-6, CCL13, CCL24, CXCL16, CSF1, and IL-1RN [24], which may have suppressed the cellular viability by reducing the proliferative potential of MDA231 cells when treated with DPMSCs in IC and SF settings, as observed in Figure 1A(i),A(ii). Here, IL1RN is linked to cancer.