The in vivo administration of the anti-IL-10 monoclonal antibody significantly enhanced host resistance at the early stage of Salmonella infection by accelerating macrophage functions and, consequently, the activation of γδT cells and enhanced levels of monokine mRNA, including IL-lα, tumor necrosis factor-α (TNF-α), and IL-12 [53]. The gene discussed is TNF; the disease is Salmonella Infections.