Our recent in vitro and in vivo studies observed that active vitamin D prevented the host from the detrimental effects of overwhelming inflammation by downregulating pro-inflammatory responses (IL-6, TNF-α, IL-8, and IL-1β) [1,2,25] in Salmonella-infected IECs and decreased the severity of colitis in mice. The gene discussed is CXCL8; the disease is colitis.