Based on family history and clinical findings, previous clinical studies have suggested that the most common mutated gene in familial DCM cases is Titin [249], followed by LMNA (lamin A/C) [250], MYH7 and MYH6 [251], SCN5A [252], MYBPC3 (Myosin-binding protein c, cardiac type) [253], and TNNT2 [254]. This evidence concerns the gene TTN and familial dilated cardiomyopathy.