PLN and familial dilated cardiomyopathy: Interestingly, several known hiPSC-derived-CMs have been established to study inherited DCM, including desmin (DES) [255], function-related protein (FKRP) [256], LMNA [257,258,259,260,261], phospholamban (PLN) [262,263,264,265], RNA binding motif protein 20 (RBM20) [266,267], TNNT2 [128,244,262,268,269], Titin [269,270,271].