Many studies have examined CMs derived from HCM patient iPSC with mutations in genes encoding sarcomeric proteins or other mutations identified in patients with HCM, such as ACTC1 (cardiac actin) [215], ALPK3 (α-kinase 3) [216], BRAF (B-Raf proto-oncogene, serine/threonine kinase) [217], FBN1 (Fibrillin 1; Marfan syndrome) [218], FXN (Frataxin; Friedreich ataxia) [219], GLA (Galactosidase α; Fabry disease) [220]. The gene discussed is FBN1; the disease is Marfan syndrome.