CYP2D6 and schizophrenia: On the other hand, by reducing the CYP2D activity in other brain regions (the frontal cortex, cerebellum), iloperidone may slow down the oxidative metabolism of neurosteroids by inhibiting their 21-hydroxylation metabolic pathway [27,75], and thus may exert beneficial effects on the symptoms of schizophrenia by affecting neuroplasticity and improving memory and cognitive functions [76,77].