CPA is the result of abnormal differentiation from ZF cells and is usually caused by somatic mutations of protein kinase cAMP-activated catalytic subunit alpha (PRKACA), GNAS complex locus (GNAS) and catenin beta 1 (CTNNB1), resulting in hypercortisolism and clinical Cushing’s syndrome [106]. Here, GNAS is linked to adrenal gland hyperfunction.