The identification and characterization of a variety of transcription factors, including those associated with monogenic diabetes (GLIS3, PDX1, PTF1A, HNF1A, HNF1B, HNF4A, FOXP3, PAX4, RFX6, GATA4, GATA6, NGN3, NEUROD1, PAX6, MNX1, NKX2.2) [12], have greatly contributed to our understanding of pancreatic development. This evidence concerns the gene GLIS3 and diabetes mellitus.