KRAS and neoplasm: To explore, whether NFATc1-dependent EZH2 induction is also evident in established PDAC, we utilized PDAC cells isolated from tumor-bearing transgenic mice characterized by constitutive nuclear NFATc1 expression and oncogenic Kras activation (cnNFATc1;KrasG12D mice, NKC-II cells [15]) and subjected these cells to siRNA-mediated NFATc1 knockdown.