Despite the significance of both factors in individually controlling tumor promoting gene signatures in PDAC development and progression [7,15,16,19], our findings suggest a chromatin-independent assembly of both proteins restrictively upon posttranslational EZH2 phosphorylation, thus pointing towards chromatin-independent implications of the NFATc1:EZH2 complex in PDAC development and progression. Here, EZH2 is linked to neoplasm.