It is noteworthy, that some of the transcription factors which have been previously linked to EZH2 activation, albeit in other cancer entities, underlie transcriptional control by NFATc1 (MYC [17,24], STAT3 [15]) or represent well-characterized NFATc1 partner proteins (STAT3 [15], ELK1 [17]). The gene discussed is NFATC1; the disease is cancer.