Given, that chromatin-independent EZH2 functions evident in glioblastoma [27] and prostate cancer [21] have been linked to posttranslational phosphorylation of the serine 21 residue of the methyltransferase (pSer21EZh2) [21,27], we explored the impact of this posttranslational EZH2 modification on NFATc1-EZH2 co-expression and NFATc1:EZH2 complex formation. This evidence concerns the gene EZH2 and Familial prostate cancer.