An original approach was tried out by Dobroff et al. [221], who found a GRP78-binding motif displayed on adeno-associated virus/phage particles and used those GRP78-targeting particles to deliver the human Herpes simplex virus thymidine kinase (HSVtk) type-1 transgene to a murine xenograft model of SUM190 human inflammatory breast carcinoma. Here, HSPA5 is linked to inflammatory breast carcinoma.