It follows from the above data that the major members of HSP70 subfamily, namely inducible forms of HSP70, GRP78 and GRP75 (mortalin) do promote tumorigenesis in the mammary gland and aggravate the course of breast cancer by stimulating the pathways, processes and phenomena that jointly mediate the tumor pathogenesis (see Figure 5). This evidence concerns the gene HSPA9 and neoplasm.