HSPA6 and neoplasm: Those antitumor effects of thymoquinone became attenuated in the case of knocking down of HSPA6 in BT-549 cells; in vivo, the high HSPA6 expression was found to be positively correlated with long overall survival in patients with breast cancer, thus suggesting the tumor-suppressive roles for this form of inducible HSP70 [193].