HSPA1A and neoplasm: Being the functional components of (epi)genetic regulation and signaling networks in malignant cells [12,20,21], HSP70s contribute to all the major manifestations of breast cancer pathogenesis such as unlimited, invasive tumor growth, EMT and formation of metastases, high resistance to therapeutics, etc. Consequently, any treatments somehow downregulating HSP70s in breast cancer cells would suppress the HSP70-dependent pathogenic mechanisms and exert some curative or tumor-sensitizing effects.