In particular, the experiments with shRNA-induced knockdown of GRP75 (HSPA9) in triple negative breast cancer MDA-MB-231 cells revealed the HSPA9-dependent mechanism of haematological and neurological expressed 1-like (HN1L)-mediated upregulation of the expression of high-mobility group protein B1 (HMGB1) that was associated with the EMT program, tumor invasion and metastasis formation in a xenograft model [146]. This evidence concerns the gene HMGB1 and neoplasm.