However, the non-selective inhibition of HSF1-dependent expression or chaperone activity of inducible HSP70 may critically decrease the resistance of patients’ normal (tumor-free) tissues to the toxic effects of chemotherapy and concomitant pathophysiological stresses such as inflammation, ischemia, acidosis, endotoxinemia and others, so that in some cases, this may have fatal consequences. This evidence concerns the gene HSPA1A and neoplasm.