As CSCs and EMT-generated CSCs-like cells are the pivotal players in the development/pathogenesis of breast cancer [6,7,8,9], the established involvement of mortalin in inducing EMT [33,34] and maintaining the stemness [34] in breast cancer cells seems to be of importance in terms of the search for appropriate targets to pharmacologically attack the malignancy (see Section 5.3). This evidence concerns the gene HSPA9 and breast cancer.