Bausero et al. [234] found that interferon-γ stimulates active release of exosomes enriched by inducible HSP70 in murine breast cancer 4T1 cells; in turn, those HSP70-containing exosomes upregulated the CD83 expression and stimulated interleukin-12 release by naive dendritic cells that suggested the HSP70-dependent enhancement of immune surveillance over the tumor. The gene discussed is HSPA1A; the disease is breast carcinoma.