HSPA5 and neoplasm: The summation on this subsection: In various breast cancer-relevant models, the GRP78-targeting natural and chemical compounds listed in Table 5 demonstrate rather good effects such as apoptosis in the tumor cells and sensitizing them to chemotherapeutic drugs [195,203,204,208,209,213,215], repression of the tumor growth and CSCs [127,206,207,215], inhibition of the tumor invasion and metastasis formation [127], and others.