Overexpression of mortalin in MDA-MB-231 cells increased their proliferation, migration and invasion; proteins known to play key roles in cell migration and EMT as well as proteins involved in focal adhesion, PI3K–Akt, and JAK–STAT signaling, were upregulated in the mortalin-expressing breast cancer cells [145]. The gene discussed is PIK3CA; the disease is breast carcinoma.