HSPA1A and breast cancer: Long non-coding RNA HOX transcript antisense RNA (lncRNA HOTAIR) and microRNA-449b-5p (miR-449b-5p) were shown to regulate the translation of HSPA1A mRNA in breast cancer MCF-7 and MDA-MB-231 cells so that lncRNA HOTAIR-targeting siRNA can confer the miR-449b-5p-mediated blockade of HSPA1A accumulation in those cells thus leading to the decrease in their HSP70-dependent radioresistance [153].