LGR6 and chronic obstructive pulmonary disease: While the expression of LGR6 has been reported before in human phagocytes, albeit its role is not completely explored, and to our knowledge LGR6 expression has not yet been documented in other immune populations, we observed increased LGR6 levels in alveolar and interstitial macrophages and in lymphoid follicles (Supplementary Figure S1B–D) of COPD and IPF lungs.