In IPF samples, LGR6 expression was generally increased in the basal progenitor populations, reaching the highest protein levels in areas of bronchiolization and honeycombing, whereas in COPD tissues, LGR6-positive basal cells were observed in damaged and inflated bronchioles and in proliferative bronchiolar lesions, but not in airways proximal to emphysematous lesions. The gene discussed is LGR6; the disease is chronic obstructive pulmonary disease.