Considering the central role of Wnt pathway regulation in COPD and IPF and the importance of LGR6-expressing cells in other lung diseases, we currently investigated the localization and the expression of LGR6 in COPD and IPF lung tissues and its potential association with senescence of progenitor cells, a detrimental mechanism for epithelial barrier integrity and function. The gene discussed is LGR6; the disease is chronic obstructive pulmonary disease.