Alongside the increased expression of LGR6 in epithelial progenitors of COPD and IPF tissues, we observed higher senescence-associated β-galactosidase (SA-β-Gal) activity and increased p16INK4A and p21CIP1 levels in LGR6-expressing cells. The gene discussed is CDKN2A; the disease is idiopathic pulmonary fibrosis.