UTX (Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X) is identified as a histone demethylase that specifically targets di- and tri-methyl groups on lysine 27 of histone H3 (H3K27me2/3), which was shown to epigenetically induce the expression of ZEB1 in brain metastases during the metastasis of lung adenocarcinoma to the brain [57]. The gene discussed is KDM6A; the disease is lung adenocarcinoma.