The E-cadherin (CDH1 gene encodes a classical cadherin of the cadherin superfamily, epithelial calcium-dependent adhesion protein, a component of the adherent junctions between epithelial cells with tumor suppressor activity) gene promoter, which possesses several regulatory sequences including three E-boxes that mediate CDH1 transcriptional repression in mesenchymal cells, is transcriptionally and epigenetically regulated during EMT [11]. Here, CDH1 is linked to neoplasm.