Further epigenetic regulation of ZEB1 depends on the protein arginine methyltransferases PRMT1, which induce the EMT process in breast cancer cells by mediating the asymmetric dimethylation of arginine 3 of histone H4 (H4R3me2as) at the ZEB1 promoter and activating its transcription [56]. The gene discussed is ZEB1; the disease is breast carcinoma.