EZH2 and lung adenocarcinoma: EZH2 (Enhancer of zeste homolog 2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3), which was shown to epigenetically suppress the expression of TWIST in brain metastases during the metastasis of lung adenocarcinoma to the brain.