In particular, E2 could retard HCC (also NASH and cirrhosis) progression, particularly in both the male gMXs + Dox zebrafish (Figure 8A,B), while 11-KT could promote HCC progression predominantly in male hMX3+Dox zebrafish (Figure 8A–C). The gene discussed is HMX3; the disease is metabolic dysfunction-associated steatohepatitis.