Masson’s trichrome stain revealed that clear HCC (Figure 6C, panel 2), steatohepatitis (Figure 6C, panel 3), and fibrosis concomitant with HCC (NAHCC) (Figure 6C, panel 4), and cirrhosis concomitant with HCC (Figure 6C, panel 4) was observed in male hMX3s (1–3) +Dox livers than in hMX3 − Dox (Figure 6C, panel 1). Here, HMX3 is linked to hepatocellular carcinoma.