We should note that the AR activation is aligned with human malignancy, such as prostate cancer, HCC, and pancreatic cancer, and that AREs, such as TGF-beta, CCRK, GRP78, and VEGF, play indispensable roles in the AR-mediated carcinogenesis [66,67,68]. Here, HSPA5 is linked to familial pancreatic carcinoma.