HMX3 and metabolic dysfunction-associated steatohepatitis: H&E staining increased Mallory−Denk bodies (MDBs) with ballooned cells and penetrated inflammatory cells, which are typical histopathological traits of NASH (Figure 5B; panels 2, 4, 6, and 8), and were more frequently (> 85%) seen in the male livers of the 8 mpf hMX3 + Dox (Figure 5B, panel 4) compared with those of controls (Figure 5B; panels 1, 3, 5, and 7).