A total of 55% male hMX3 + Dox and 37% male gMX2 + Dox fish had advanced HCC, only 18% hMX3 + Dox and 8% gMX3 + Dox females had clear HCC, and the rest had NAFL or NASH compared with MXs − Dox fish (Figure 6D). Here, HMX3 is linked to metabolic dysfunction-associated steatohepatitis.