For example, CAF EV-encapsulated miR-181d-5p and miR-34a-5p downregulated the tumor-suppressor genes HOXA5 and AXL, respectively, which is associated with inhibition of proliferation and mobility via the AKT/GSK-3β/β-catenin signaling pathway [38,39]. Here, AKT1 is linked to neoplasm.