Overall, based off the available literature, future ALD research should investigate if an increase in MCP-1 or chitotriosidase occurs before, or as a consequence of, the neuroinflammation and damage to the BBB during the onset of cerebral ALD, and if they could be an early predictive biomarker for cerebral ALD. This evidence concerns the gene CHIT1 and X-linked adrenoleukodystrophy.