Given the anti-inflammatory effects of Annexin A1, and its interaction with Fpr2, in protection against organ fibrosis, the role of Annexin A1 in kidney fibroblasts has been examined utilizing an animal model of renal fibrosis induced by inhibiting angiotensin II type 1 receptor with L-158.809 during the nephrogenic period [28]. Here, ANXA1 is linked to renal fibrosis.