In this context, it is noteworthy that Annexin A1 gene expression is upregulated in renal cortex of the deoxycorticosterone-acetate/NaCl rat model of hypertension [45], a condition associated with marked kidney inflammation, fibrosis and dysfunction; increased Annexin A1 expression likely serves as a compensatory mechanism curtailing fibrosis. Here, ANXA1 is linked to hypertensive disorder.