NES and metastatic malignant neoplasm in the lymph nodes: Interestingly, when Bromińska et al. [54] analyzed immunohistochemical staining for nestin in 35 LCNEC, 15 TC, and 5 AC biopsies, they found that nestin expression did not correlate with lymph node metastasis, maximum size of the lesion, Ki-67 expression, or survival.