Simon et al. [178] further analyzed memory B cells subsets into CD19+IgD-CD27-CD38+ double negative (DN)-1, CD19+IgDloCD27+CD38+ unswitched, CD19+IgD-CD27+CD38+CD95- resting switched, and CD19+IgD-CD27-CD38-CD95+ active switched memory (ASM) B cells (ASM-B) in SSc patients. The gene discussed is CD27; the disease is systemic sclerosis.