Chen et al. [74] concluded that hypomethylation of IFN-related genes in CD4+ T cell is a common epigenetic feature of autoimmune disease including Grave’s disease, rheumatoid arthritis, systemic lupus erythematosus, and SSc patients, and the DNA methylation profile of IFN-related genes could become promising biomarkers for autoimmune diseases. This evidence concerns the gene CD4 and autoimmune disease.