Moreover, Lomeli-Nieto et al. [144] demonstrated the polymorphic TNF-α promoter regions, TNF-α−308 and TNF-α−258, in SSc patients in that TNF-α−308 G > A and TNF-α −238 G > A polymorphisms were associated with higher serum levels of TNF-α and anti-RNA polymerase III antibody. Here, TNF is linked to systemic sclerosis.