In pancreatic cancer ACEA induced ROS-mediated autophagy via activation of AMPK, inhibition of energetic metabolism; it decreased Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and Pyruvate Kinase M2 (PMK2) expression and enhanced the anticancer potential of gemcitabine [113,114]. Here, GAPDH is linked to pancreatic neoplasm.