CNR1 and colorectal carcinoma: Accordingly, González et al. reported that the compound, given with Cannabigerol (CBG), weakly antagonist at CB1R, and O-1602 (synthetic GPR55 agonist) induced apoptosis, reduced angiogenesis, tumour volume, and aberrant crypt foci (ACF) on colorectal cancer (CRC) models in vivo [162].