Induction of PPARγ dependent apoptosis through increased levels of COX2-dependent prostaglandinsReduction in cell migration accompanied with decreased PAI-1Induction of ICAM-1 in cancer cells leading to lymphokine-activated killer (LAK) cell-mediated cytotoxicityUpregulation of ICAM-1 and TIMP-1 levels, decreasing cell migration via CBRs, TRPV1 and p42/44 MAPK. The gene discussed is PTGS2; the disease is cancer.