DISC1 and schizophrenia: Of note, Rac1 is possibly involved in the pathogenesis of complex neuropsychiatric disorders such as schizophrenia, especially in relation to the specific risk genes DISC1 (Disrupted in schizophrenia 1, OMIM * 605210), KALRN (Kalirin, OMIM * 604605), and TIAM1 (T-cell lymphoma invasion and metastasis 1, OMIM * 600687) [48,49].