CD8A and neoplasm: Therefore, the increase in the number of CD8+ cells upon PU-WS13 treatment in our preclinical model, which is associated with reduced tumor growth, might be due to the decrease in tumoral collagen content, facilitating the infiltration of CD8 T cells or/and to the decrease in M2-like macrophages and its consequences on the mobility of CD8+ T cells and infiltration into the tumor [31].