TARDBP and amyotrophic lateral sclerosis: From a pathological point of view, ALS- and FTLD-associated mutations in C9ORF72 and TARDBP have shown similar effects on various mitochondrial parameters, such as increased oxidative and endoplasmic reticulum (ER) stress, impaired mitochondrial transport in axons, abnormal morphology, reduced ATP production, Ca2+ signaling, mitochondrial membrane potential, and activity of mitochondrial respiratory complexes [161,162,163,164,165,166,167], all reviewed in References [135,140].