It is worth noting that such enhanced platelet apoptosis is especially observed in ITP patients carrying anti-GPIb-V-IX (anti-GPIbα) or anti-αIIbβ3 antibodies, but not in subjects with anti-α2β1 antibodies (binding to the fewer copies of integrin α2β1) [35]. The gene discussed is GP1BA; the disease is autoimmune thrombocytopenic purpura.