A study by Salas-Pérez et al. [45] assessed a number of candidate genes involved in longevity-regulating pathways and found that FOXO3 hypermethylation in leukocytes was associated, albeit weakly, with higher triglyceride levels and insulin resistance, which are risk factors for cancer and premature death; CpGs within six genes (MTOR, ULK1, ADCY6, IGF1R, CREB5, and RELA) were identified as being associated with metabolic variables. This evidence concerns the gene CREB5 and cancer.