Moreover, repletion of 25(OH)D3 significantly decreased expression of upregulated genes (Csrp3, Cyfip2, Myl2) while increasing the expression of downregulated genes (Atf3, Fos, Itpr1) relative to repletion of 1,25(OH)2D3 in CKD mice. This evidence concerns the gene MYL2 and chronic kidney disease.