Upregulated genes included Atp2a2, Csrp3, Cyfip2, Fhl1, Gng2, Myl2, Tnnc1 and Tpm3 whereas downregulated genes were Atf3, Fos, Itpr1 and Maff in 12-month-old CKD mice versus age-appropriate sham mice. This evidence concerns the gene ATP2A2 and chronic kidney disease.