Moreover, repletion of 25(OH)D3 significantly decreased expression of upregulated genes (Csrp3, Cyfip2, Myl2) while increasing the expression of downregulated genes (Atf3, Fos, Itpr1) relative to repletion of 1,25(OH)2D3 in CKD mice. The gene discussed is CYFIP2; the disease is chronic kidney disease.