We showed that repletion of 25(OH)D3 significantly decreased inguinal WAT expression of Cox2, Pgf2α, Tlr2, Myd88 and Traf6 in CKD mice and that the effect was significantly stronger than seen with 1,25(OH)2D3 repletion in CKD mice (Figure 3D–H). This evidence concerns the gene TRAF6 and chronic kidney disease.