Moreover, repletion of 25(OH)D3 significantly decreased expression of upregulated genes (Csrp3, Cyfip2, Myl2) while increasing the expression of downregulated genes (Atf3, Fos, Itpr1) relative to repletion of 1,25(OH)2D3 in CKD mice. The gene discussed is ITPR1; the disease is chronic kidney disease.