Interestingly, Painter et al. reported defective intraphagolysosomal HOCl production in granulocytes from CF patients [24] and reported three mechanisms mediating the neutrophil-mediated killing of Pseudomonas Aeruginosa: (1) CFTR-dependent and oxidant-dependent, (2) chloride-dependent but not CFTR- and oxidant-dependent, and (3) independent of any of the tested factors [25]. Here, CFTR is linked to cystic fibrosis.