Remarkably, in an analysis of MECL-1/β2i and LMP7/β5i double gene-deficient mice, Zaiss et al. [82] noticed the development of multiple autoimmune syndromes including dermatitis, diabetes insipidus, and latent insulin-dependent diabetes mellitus (IDDM) following full-body irradiation and bone marrow transfer. Here, PSMB8 is linked to type 1 diabetes mellitus.