Both studies in mouse models and meta-analyses of human genetic data indeed have linked immunoproteasome subunit deficiency (in mice) and specific polymorphisms in the immunoproteasome subunit genes LMP2/β1i and LMP7/β5i (in humans) to different, in part CD8+ T-cell-mediated autoimmune syndromes such as T1D. The gene discussed is PSMB8; the disease is type 1 diabetes mellitus.