ZG16 and adenoma: The alteration of mucus components in UC patients was investigated by Van der Post et al. Together with MUC2, structural components such as Fc-gamma binding protein (FCGBP), SLC26A3/DRA (downregulated in adenoma) and Zymogen granule protein 16 (ZG16) are found to be reduced in the colonic mucus of UC patients [114].