AGT and Hypertension: P2Y6R-deficient mice exhibit a decrease in Ang II-induced pathological arterial remodeling in response to hypertension than wild-type mice [503] P2Y1R and P2Y13R are expressed in pulmonary artery vasa vasorum endothelial cells and functionally involved in intracellular and mitochondrial Ca2+ regulation associated with pathologic angiogenic expansion of the vasa vasorum network [479,505].