The weakest effect of ClpP deletion on a ClpX interactor in the above experiments was observed for the PD-associated UPRmt sensor CHCHD2 [25,45], in agreement with previous observations that ClpP-null mice do not show widespread strong UPRmt [79] or the typical distribution of PD pathology [2,80]. The gene discussed is CLPX; the disease is Parkinson disease.