CLPP and Perrault syndrome 3: Interestingly, ClpP-mutant mice and patients affected by Perrault syndrome type 3 (PRLTS3) display not only primary ovarian insufficiency, as in other forms of PRLTS, but also azoospermia [15,21], indicating that germ cell differentiation and meiosis have profound defects, while mitotic proliferation rates of ClpP-null mouse cells appear normal.