Therefore, in comparison to the surrounding normal tissues, upregulated GPR56 expression is detected in many human cancer tissues, including breast and pancreatic cancers, colorectal, renal, cervical, esophageal squamous cell carcinoma (ESCC), non-small-cell lung carcinoma (NSCLC), and epithelial ovarian tumors [80,81,82,90,96,97]. Here, ADGRG1 is linked to esophageal squamous cell carcinoma.