Importantly, GPR56 was often detected and implicated in the development of many different types of cancers, including melanoma, breast, non-small cell lung, esophageal squamous cell cancer [80], ovarian, colon, pancreatic carcinoma [81,82], glioblastoma/astrocytoma [83], and leukemia [79,84,85]. This evidence concerns the gene ADGRG1 and leukemia.