ADGRG1 and colorectal cancer: Likewise, Lim et al. examined GPR56 expression levels in the tissue samples of colorectal cancer (CRC) patients by immunohistochemistry and found that the GPR56high expression group had a lower 5-year overall survival rate than the GPR56low expression group, suggesting that the GPR56 expression level might be a prognostic indicator of CRC [89].