RUNX1 and acute lymphoblastic leukemia: ETV6-RUNX1-like ALL is characterized by a gene expression profile and immunophenotype (CD27+, CD44low/negative) similar to that of ALL with ETV6-RUNX1 rearrangement [27,28]; this subtype occurs almost exclusively in children (approximately 3% of pediatric ALL) and is associated with relative favorable outcomes [29].