The genomic and epigenomic profiles studies have divided T-ALL into four major subtypes: (i) TLX1 (T cell leukemia homeobox protein 1, previously termed HOX11), (ii) LYL1, (iii) TAL1/LMO2, and (iv) TLX3 (previously termed HOX11L2), although the prognostic and therapeutic significance of the subtypes has not been well-elucidated [57]. Here, LYL1 is linked to acute lymphoblastic leukemia.