The recurrent mutated genes encoding chromatin modifiers and epigenetic regulators have a higher incidence among TLX3-positive and TLX1-positive cases, and particularly inactivating mutations of the gene encoding the plant homeodomain-like finger family member PHF6 were reported to occur in approximately 16% of pediatric and 33% of adult T-ALL cases [70]. This evidence concerns the gene PHF6 and acute lymphoblastic leukemia.