In addition, the inactivating mutations in the gene that encodes the tumor-suppressor FBXW7 are also commonly observed in T-ALL patients, which regulates the proteasome-mediated deregulation of NOTCH1, resulting in the loss of NOTCH1 protein deregulation and subsequent activation of NOTCH1 signaling [62]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.