Moreover, CXCL16 deficiency had been shown to impair the aggregation and myofibroblast production of bone-marrow derived fibroblasts in the kidney and the development of renal fibrosis, while targeted deletion of CXCL16 inhibited myofibroblast activation, reduced collagen deposition, and suppressed collagen I and fibronectin expression [39]. The gene discussed is FN1; the disease is renal fibrosis.