Evidence was accumulated that chemokines and their receptors had a strong relationship with poor clinical outcomes in different tumor progression [30], such as that CCR6 and CXCL16/CXCR6 were involved in regulation proliferation, metastasis, and EMT in ESCC and Gastric cancer tumorigenesis [31,32]. The gene discussed is CXCL16; the disease is esophageal squamous cell carcinoma.