For instance, miR-155, despite being a negative regulator of leptin expression, also downregulates resistin, an adipokine with inverse biological properties to adiponectin, the serum levels of which are elevated in the course of obesity and correlate with the intensity of obesity-associated metabolic inflammation, insulin resistance, NAFLD, atherosclerosis and cardiovascular diseases. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.