It has been shown that ouabain decreases the levels of phopho-Tau both in vitro (human cells from neuroblastoma SH-SY5Y and primary neurons treated with 500 nM ouabain for 8 h) and in vivo (TauP301L mice with induced memory impairment and elevated tau level, behavioral tests after administration of 1.5 μg·kg−1 ouabain). This evidence concerns the gene MAPT and memory impairment.