Clinically, a mutation in the gene coding for TNSALP has been closely associated with a severe skeletal deformity disease termed “hypophosphatasia (HPP),” which is characterized by several pathological abnormalities, including rickets, osteomalacia, epilepsy-like seizures associated with vitamin B6 deficiency, muscle weakness, and respiratory disturbance [14,15]. Here, ALPL is linked to hypophosphatasia.