ATR and autosomal recessive primary microcephaly: Mutations in any one of at least 16 centrosomal protein-encoded genes result in a spectrum of disorders that cause developmental microcephaly (autosomal recessive primary microcephaly/MCPH) and primordial dwarfisms (Seckel syndrome/SCKL and others) [28,42,43,44,45,46,47,48,49].