CAMP and steatosis: We have previously shown in a mouse model of ALD that lacking CRAMP, the murine ortholog of LL37, exacerbated binge-on chronic alcohol-induced liver injury and steatosis through inhibiting LPS and uric acid-mediated inflammasome activation [13], however, the role of CRAMP/LL37 in alcohol-induced liver injury in high-fat-diet-primed animals has not been described.