SPRY3 and myocardial ischemia: Aggravating: Promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase C epsilon [250], inhibits the mitosis of cardiomyocytes [251], promotes fibrosis via targeting sprouty3 [252];Attenuating: Promotes post-MI cell proliferation and reduced cell apoptosis in vitro via cyclooxygenase-2 [253]