Despite the beneficial acute effects in GSIS potentiation, various studies have shown that T2D patients present high levels of plasma FFAs [49,50,51] and that deleterious parameters related to this condition, such as impaired insulin secretion and glucose intolerance are associated with the elevated levels of saturated FAs, including palmitic acid (C16:0) and stearic acid (C18:0) [52,53,54]. The gene discussed is INS; the disease is type 2 diabetes mellitus.