DUX4 and facioscapulohumeral muscular dystrophy: The post-transcriptional effects of DUX4 on mRNA metabolism also include the increased stability and accumulation of a number of transcripts, among which is mRNA encoding for the transcription factor MYC, with a 2-fold increase in cells ectopically expressing DUX4 and in DUX4-positive FSHD muscle cells [42,73].