To better elucidate the role of FAPs in FSHD pathogenesis, it would be relevant to investigate whether the changes in FAPs compartment observed in iDUX4pA-HSA mice are a feature of FSHD patient muscle biopsies and whether, differently from the mouse model, endogenous DUX4 and its targets are elevated in human FAPs. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.