Wang et al. showed that a SIRT2 inhibitor rescued the cognitive impairment in amyloid precursor protein/presenilin 1 (APP/PS1) mice via the repression of Reticulon 4b deacetylation followed by the inhibition of beta-site amyloid precursor protein cleaving enzyme 1 [92]. This evidence concerns the gene PSEN1 and Cognitive impairment.