In terms of the relationship between SIRT2 and other HIFs, Hu et al. reported that SIRT2 reduced the expression of VEGFD and lymphangiogenesis in hypoxia-induced head and neck cancer cells via deacetylation of HIF-2α and decreased transcriptional activity of HIF-2α-target genes [26]. The gene discussed is EPAS1; the disease is head and neck cancer.