Experimentally, SIRT2 is reported to be targeted by miR-212-5p (which is expressed from the 5′ end of the miR-212 precursor) in human colorectal cancer (CRC) via its 3′-UTR, leading to posttranscriptional downregulation of SIRT2 [61]. The gene discussed is SIRT2; the disease is colorectal cancer.