TCF7L2 and autism: In the UpRGs PPI network, we identified seven known autism risk genes (Simons Foundation Autism Research Initiative, SFARI Gene): PON1, MAGEL2, PPP1R1B, SLC29A4, TTC25, DYDC2, and FAM92B that played the central role in the clustered PPI network (red circle in Figure 2D); and six known autism risk genes: TTN, TCF7L2, RORA, FOXP2, RIMS3, and SATB2 in the DownRGs PPI network (green circle in Figure 2D).