Upregulation of lncRNA C/EBPβ and C/EBP homologous protein (CHOP) in MDSCs induces expression of immunosuppressive factors, such as NO synthase 2, NADPH oxidase 2, Arg1 and cyclooxygenase-2, via interactions with CHOP and liver-enriched inhibitory protein (LIP), leading to activation of CCAAT-enhancer-binding protein (C/EBPB) and augmentation of tumor growth in many cancers [74]. The gene discussed is DDIT3; the disease is cancer.