The lncRNAs small nucleolar RNA host gene 1 (lnc-SNHG1), epidermal growth factor receptor (lnc-EGFR) and insulin receptor precursor (lnc-INSR) have been reported to reduce the cytotoxic activities of CD8+ T cells within the TME, by accelerating the polarization of tumor infiltrated CD4+ T lymphocytes (TILs) into regulatory Tregs (CD4+/CD25+/Foxp3+ T cells) [38,39,40]. Here, CD4 is linked to neoplasm.