In addition, overexpression of lncRNA ribonuclease P RNA component H1 (RPPH1) in CRC promotes tumor cell proliferation and metastasis by interacting with the epithelial to mesenchymal transition (EMT)-inducer tubulin beta 3 class III (TUBB3) and facilitating exosome-mediated macrophage M2 polarization [91]. This evidence concerns the gene TUBB3 and neoplasm.