Conversely, other lncRNAs such as HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) and metastasis associated lung adenocarcinoma transcript 1 (MALAT1), have been reported to negatively affect the proportion of MDSCs in peripheral blood mononuclear cells (PBMCs) and downregulate their immunosuppressive activity in cancer [69,73]. Here, MALAT1 is linked to cancer.