Multiple modifications on cancer cell membranes such as underexpression of MHC class I antigens, upregulation of inhibitory immune checkpoint molecules, like programmed death-ligand 1 (PD-L1), and reduced presentation of tumor associated and tumor specific antigens (TAA and TSA) are among the most prevalent mechanisms associated with tumor escape from host adaptive immune-surveillance [25,26]. Here, CD274 is linked to neoplasm.