LncRNA small nucleolar RNA host gene 20 (lnc-SNHG20) induces p-ATM, p-JAK1/2 and PD-L1 in esophageal squamous cell carcinoma (ESCC), resulting in ESCC progression and metastasis [125], whereas upregulation of lncRNA NK2 homeobox 1 antisense RNA 1 (NKX2-1-AS1) in human lung adenocarcinoma (LUAD) negatively regulates CD274/PD-L1 axis and cancer cells migration [126]. The gene discussed is CD274; the disease is cancer.