Moreover, lncRNA growth arrest-specific transcript 5 (GAS5) is a key player in maintaining an immunosuppressive microenvironment in CRC by regulating the expression of vascular endothelial growth factor A (VEGF-A) and IL-10 in cancer cells, via modulation of NF-κB and extracellular signal-regulated kinase 1/2 (ERK1/2) pathways, respectively [120]. This evidence concerns the gene MAPK3 and colorectal carcinoma.