Accordingly, elevated levels of long intergenic noncoding RNA POU3F3 (linc-POU3F3) in gastric cancer (GC) patient-derived Tregs augments Treg distribution, through modulation of TGF-β signaling pathway [41], while lncRNA Flatr enhances the immunosuppressive function of Tregs by boosting FOXP3 expression [42]. Here, POU3F3 is linked to gastric cancer.