Furthermore, lncRNA HOXA distal transcript antisense RNA (HOTTIP) enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating PD-L1 in neutrophils [127], while expression of lncRNA actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) in infiltrating lymphocytes in nasopharyngeal carcinoma (NPC) is positively correlated with expression of the immune escape receptor PD-1 on CTLs, distant metastasis and poor prognosis [128]. The gene discussed is AFAP1; the disease is ovarian carcinoma.