Expression of another BCBM regulator, the lncRNA associated with BCBM (lnc-BM), in BC cells has been associated with recruitment of macrophages in the brain via STAT3-dependent induction of C–C motif chemokine ligand 2 (CCL2), resulting in IL-6 accumulation and feedback hyperactivation of the lnc-BM/JAK2/STAT3 loop and hence further BCBM enhancement [94]. This evidence concerns the gene STAT3 and breast cancer.