Concomitantly, in colorectal cancer (CRC) xenograft mouse models induction of lncRNA GM16343 in IL-36-stimulated mouse CD8+ T cells increased their interferon gamma (IFN-γ) secreting ability in the TME and reduced tumor diameter, thus suggesting a critical role of lncRNA GM16343 in reinforcing the CD8+ T cell-mediated anti-tumor immune response [48]. This evidence concerns the gene CD8A and neoplasm.