Most of the tumor-derived MDSCs have lost their ability to differentiate into mature granulocytes, monocytes and macrophages, while they accelerate tumor progression by dramatically blocking T cell-induced antitumor responses and enhancing Tregs through release of Arg1, reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOs) [68,70,71,72]. This evidence concerns the gene NOS2 and neoplasm.