Furthermore, FOXC1-mediated overexpression of lncRNA LINC00301 in NSCLC cells is associated with an increase in Treg and a decrease in CD8+ T cell populations, through activation of the FOXC1/LINC00301/EZH2/EAF2/pVHL/HIF1α and FOXC1/LINC00301/miR-1276/HIF1-α pathways [86]. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.