HIF1A and melanoma: In support of this, in vivo experiments demonstrated that Mexo influenced the bio-distribution of free melanoma cells within a sentinel lymph node and induced an upregulation of genes involved in cell recruitment, ECM remodelling and vascular proliferation factors, such as tumour necrosis factor (TNF)-α, VEGF, HIF-1 and a urokinase plasminogen activator [54,93].