Mexo were described to vehiculate functionally active molecules involved in angiogenesis and in tumour growth and metastasis formation, such as interleukin (IL)-6, vascular endothelial growth factor (VEGF) and different metalloproteinase (MMPs) [53,54], as well as miRNAs, such as miR-494 [55], miR-9 [56], miR-125b [57], miR-155-5p [58], miR-91, Let-7a, Let-7i [59], and miR-222 [60]. This evidence concerns the gene VEGFA and neoplasm.