Because the C-terminal of LPA2 has a special sequence that binds to class I PDZ domains, interactions with PDZ-containing proteins modulate LPA2’s effects on cellular signaling, enabling interactions with the leukemia-associated Rho guanine nucleotide exchange factor (Rho GEF) and PDZ-Rho GEF [310]. This evidence concerns the gene LPAR2 and leukemia.