Overexpression or mutation of Gα12/13 or Gα12/13-linked GPCRs such as PAR1 or thromboxane A2 receptor (TBXA2R) has been proven to be transformative and considerably boost the invasive potential of many cancer types, including breast, prostate, and hepatocellular carcinomas [30,118,135,136,137]. This evidence concerns the gene TBXA2R and hepatocellular carcinoma.