Emerging evidence revealed that elevated levels of plasma cytokines, such as IL-1β, IL-2, IL-4, IL-6, IL-7, IL-10, IL-17, IL-18, TNF-α, vascular endothelial growth factor (VEGF), granulocyte-macrophage colony-stimulating factor (GM-CSF), IFN-γ, etc. and chemokines (CXCL-8, CXCL-10, CCL-1, CCL-2, CCL-3, CCL-4, etc.)are directly associated with COVID-19 severity [36,37]. The gene discussed is IL6; the disease is COVID-19.